November 27, 2025
Early in intern year, a patient’s death from a ruptured cerebral arteriovenous malformation shatters a trainee’s medical innocence, and he must find the wherewithal to inform the family.
Mark A. Pacult
November 27, 2025
In this pilot study, a method of imaging in primary aldosteronism was developed with the use of an aldosterone synthase (CYP11B2)–specific 18F-labeled radioligand for use with positron-emission tom...
Erik Årstad, Bryan Williams
November 27, 2025
A 57-year-old woman with a history of subarachnoid hemorrhage was admitted to the hospital because of visual disturbances involving the right visual field, as well as episodes of shaking of the rig...
Nancy Wang, Anthony R. Russo
November 27, 2025
Approximately half the worldwide population is at risk for dengue. No antiviral prophylaxis or treatment options are available.In a phase 2a, double-blind, randomized trial, we assigned healthy adu...
Anna P. Durbin, Freya Rasschaert
November 27, 2025
In patients with an acute coronary syndrome who undergo coronary-artery revascularization with stent implantation, dual antiplatelet therapy with aspirin and a P2Y12 inhibitor (e.g., clopidogrel, t...
Jane A. Leopold
November 27, 2025
NOS host Lisa Rosenbaum and her guests lay bare the joys and rewards of full-spectrum primary care practice and consider ways of stoking students’ passion, and strengthening their ability, to pursu...
November 27, 2025
An appropriate duration of dual antiplatelet therapy after percutaneous coronary intervention for acute myocardial infarction that has been treated with guideline-recommended complete revasculariza...
Giuseppe Tarantini, Guillaume Cayla
November 27, 2025
Whether potent P2Y12 inhibitor monotherapy without aspirin initiated shortly after successful percutaneous coronary intervention (PCI) is effective and safe for patients with acute coronary syndrom...
Patricia O. Guimarães, Pedro A. Lemos
November 27, 2025
Hereditary hemorrhagic telangiectasia (HHT) can cause recurrent, severe epistaxis, as well as anemia and reduced quality of life. The disease remains without licensed therapies worldwide.In this pr...
Hanny Al-Samkari, Hans-Jurgen Mager
November 27, 2025
Osilodrostat, a dual aldosterone synthase and 11B-hydroxylase inhibitor, controlled bilateral macronodular adrenal hyperplasia in a patient with primary aldosteronism.
Carine Richa, Jacques Young
November 27, 2025
Angiopoietin-like protein 3 (ANGPTL3) inhibits lipoprotein and endothelial lipases. ANGPTL3 loss-of-function genetic variants are associated with decreased levels of low-density lipoprotein cholest...
Luke J. Laffin, Steven E. Nissen
November 27, 2025
A confluence of interrelated factors has put past progress in public health at serious risk in the United States. How did we get here, and what can public health professionals do about it?
