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Latest medical updates

June 26, 2025

Four patients with infantile-onset Pompe’s disease received a single intravenous injection of an adeno-associated virus serotype 9 vector carrying codon-optimized complementary DNA encoding human a...

Xiuwei Ma, Zhichun Feng

June 26, 2025

This article from the FDA compares broad U.S. recommendations on Covid vaccination with those from other countries and announces the adoption of an evidence-based approach to such recommendations.

Vinay Prasad, Martin A. Makary

June 26, 2025

A patient with reversible blindness and surface failure in one eye underwent autologous transplantation of the entire bulbar ocular surface obtained from his other eye (shown in a video).

Enrica Sarnicola, Vincenzo Sarnicola

June 26, 2025

A 59-year-old man presented with a 5-hour history of severe, pleuritic chest pain after vomiting. CT of the chest revealed air in the mediastinum extending up to the neck and perforation of the eso...

Penghui Wei, Wenyong Zhu

June 26, 2025

A 63-year-old woman was evaluated for dyspnea and edema. Soft-tissue thickening was noted in the retroperitoneum and mediastinum and around the heart and vessels. A diagnosis was made.

Malissa J. Wood, Bailey M. Hutchison

June 26, 2025

To the Editor: In the Case Record (Feb. 20 issue)1 regarding a patient with hepatic atrophy due to chronic portal-vein thrombosis (PVT), discussant Bromberg notes that previous endothelial injury f...

June 26, 2025

To the Editor: In the VANISH2 trial (Feb. 20 issue),1 Sapp and colleagues found that catheter ablation as first-line treatment for ventricular tachycardia in patients with ischemic cardiomyopathy a...

June 26, 2025

Stroke is a devastating complication of transcatheter aortic-valve implantation (TAVI), compromising its remarkable improvements in survival and quality of life. Although TAVI-related stroke has be...

Hani Jneid

June 26, 2025

A 69-year-old man with multiple myeloma presented with an enlarging purple skin mass on his right shoulder at the surgical site of a recent intramedullary nailing of a humerus fracture.

Madeline Conlon, Katie McBee

June 26, 2025

Starting in January 2025, various government health datasets were removed, restored, manipulated, or not posted as planned. The consequences of these changes could be far-reaching.

Janet Freilich, Aaron S. Kesselheim

June 26, 2025

In phase 2 trials involving patients with stage 2 or 3 fibrosis caused by metabolic dysfunction–associated steatohepatitis (MASH), efruxifermin, a bivalent fibroblast growth factor 21 (FGF21) analo...

Mazen Noureddin, Kitty Yale

June 26, 2025

First-line treatment with encorafenib plus cetuximab (EC) with or without chemotherapy (oxaliplatin, leucovorin, and fluorouracil [mFOLFOX6]) for BRAF V600E–mutated metastatic colorectal cancer, an...

Elena Elez, Scott Kopetz

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