May 29, 2025
This Double Take video explores the differential diagnosis for progressive dyspnea and cough and highlights the importance of taking a thorough history.
Suellen Li, Caren G. Solomon
May 29, 2025
Giant-cell arteritis is a systemic vasculitis with limited treatment options. The efficacy and safety of upadacitinib — a selective Janus kinase (JAK) inhibitor that blocks the signaling of several...
Daniel Blockmans, Peter A. Merkel
May 29, 2025
A 68-year-old man with cirrhosis presented with a 2-day history of severe abdominal pain. CT showed thrombosis of the superior mesenteric vein.
Chih-Yang Hsiao, Chih-Yang Chan
May 29, 2025
A 52-year-old man was evaluated in a hospital in Argentina for fever and hypoxemic respiratory failure. Imaging showed pulmonary opacities, and the hematocrit was 56.9%. A diagnosis was made.
Martín Hunter, Maria V. Leone
May 29, 2025
To the Editor: In the comparison of colchicine with placebo in the CLEAR trial, Jolly et al. (Feb. 13 issue)1 found that among patients who had an acute myocardial infarction, treatment with colchi...
May 29, 2025
Twenty children with relapsed or refractory immune thrombocytopenia were treated with daratumumab. Most patients had a response, platelet counts increased quickly, and responses were durable in hal...
Ting Sun, Lei Zhang
May 29, 2025
To the Editor: In his review article, Haber (Jan. 16 issue)1 discusses ways of identifying and treating alcohol use disorder. We seek clarification regarding the use of pharmacotherapy for alcohol ...
May 29, 2025
A 47-year-old man with type 2 diabetes presented with several years of progressive growth of pendulous skin lesions on his lower abdominal wall where he had repeatedly injected insulin.
Daniel Connors, Philip Chia
May 29, 2025
Recently, a federal judge struck down an FDA rule on laboratory-developed tests. If this invalidation stands, it will have consequences for clinical care and the FDA’s authority over medical devices.
Rachel E. Sachs, Patricia J. Zettler
May 29, 2025
A total of 14 million Medicare beneficiaries receive the Low-Income Subsidy (LIS), which reduces cost sharing in Medicare Part D. Losing the LIS may impede medication access and affect mortality.Us...
Eric T. Roberts, José F. Figueroa
May 29, 2025
This article describes how machine-learning tools were used to design novel protein inhibitors that proved effective against snake-venom toxins in mice.
José María Gutiérrez
May 29, 2025
The cardiovascular safety of oral semaglutide, a glucagon-like peptide 1 receptor agonist, has been established in persons with type 2 diabetes and high cardiovascular risk. An assessment of the ca...
